| Predicate | Object |
|---|---|
| rdf:type | |
| http://www.biopax.org/relea... |
cpath:CPATH-LOCAL-262561,
cpath:CPATH-LOCAL-262561,
cpath:CPATH-LOCAL-262562,
cpath:CPATH-LOCAL-262562,
cpath:CPATH-LOCAL-262563,
cpath:CPATH-LOCAL-262563,
cpath:CPATH-LOCAL-262564,
cpath:CPATH-LOCAL-262564,
cpath:CPATH-LOCAL-262565,
cpath:CPATH-LOCAL-262565,
cpath:CPATH-LOCAL-262566,
cpath:CPATH-LOCAL-262566,
cpath:CPATH-LOCAL-262567,
cpath:CPATH-LOCAL-262567,
cpath:CPATH-LOCAL-262568,
cpath:CPATH-LOCAL-262568,
cpath:CPATH-LOCAL-270222,
cpath:CPATH-LOCAL-270222
|
| http://www.biopax.org/relea... |
Sprouty-related, EVH1 domain-containing protein 2,
Sprouty-related, EVH1 domain-containing protein 2
|
| http://www.biopax.org/relea... |
SPRE2_HUMAN,
SPRE2_HUMAN
|
| http://www.biopax.org/relea... | |
| http://www.biopax.org/relea... |
Spred-2,
Spred-2
|
| http://www.biopax.org/relea... |
FUNCTION: Tyrosine kinase substrate that inhibits growth-factor- mediated activation of MAP kinase. SUBUNIT: Interacts with Ras (By similarity). Homodimer and heterodimer. Able to interact with SPRED1 to form heterodimers. SUBCELLULAR LOCATION: Membrane; Peripheral membrane protein; Cytoplasmic side (By similarity). Cytoplasmic vesicle, secretory vesicle membrane; Peripheral membrane protein; Cytoplasmic side (Potential). Cytoplasm. Note=Especially found in the cytoplasm of the stratum spinosum cells called membrane-coated granules. TISSUE SPECIFICITY: Expressed in liver, skin, small intestine, salivary gland and prostate. PTM: Phosphorylated on tyrosine. Phosphorylation of Tyr-228 and Tyr-231 are required for ubiquitination. PTM: Ubiquitinated; leading to degradation by the proteasome. SIMILARITY: Contains 1 KBD domain. SIMILARITY: Contains 1 SPR (sprouty) domain. SIMILARITY: Contains 1 WH1 domain. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.,
FUNCTION: Tyrosine kinase substrate that inhibits growth-factor- mediated activation of MAP kinase. SUBUNIT: Interacts with Ras (By similarity). Homodimer and heterodimer. Able to interact with SPRED1 to form heterodimers. SUBCELLULAR LOCATION: Membrane; Peripheral membrane protein; Cytoplasmic side (By similarity). Cytoplasmic vesicle, secretory vesicle membrane; Peripheral membrane protein; Cytoplasmic side (Potential). Cytoplasm. Note=Especially found in the cytoplasm of the stratum spinosum cells called membrane-coated granules. TISSUE SPECIFICITY: Expressed in liver, skin, small intestine, salivary gland and prostate. PTM: Phosphorylated on tyrosine. Phosphorylation of Tyr-228 and Tyr-231 are required for ubiquitination. PTM: Ubiquitinated; leading to degradation by the proteasome. SIMILARITY: Contains 1 KBD domain. SIMILARITY: Contains 1 SPR (sprouty) domain. SIMILARITY: Contains 1 WH1 domain. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.
|
| skos:exactMatch | |
| skos:closeMatch |