Linked Life Data

CPATH-59047

Source:http://cbio.mskcc.org/cpath#CPATH-59047

Statements in which the resource exists.
SubjectPredicateObjectContext
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cpath:CPATH-59047http://www.biopax.org/relea...cpath:CPATH-LOCAL-248871lld:biogrid
cpath:CPATH-59047http://www.biopax.org/relea...NEDD8-activating enzyme E1 catalytic subunitlld:biogrid
cpath:CPATH-59047http://www.biopax.org/relea...UBA3_YEASTlld:biogrid
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cpath:CPATH-59047http://www.biopax.org/relea...6.3.2.-lld:biogrid
cpath:CPATH-59047http://www.biopax.org/relea...RUB1-activating enzyme E1lld:biogrid
cpath:CPATH-59047http://www.biopax.org/relea...Ubiquitin-activating enzyme E1 3lld:biogrid
cpath:CPATH-59047http://www.biopax.org/relea...Ubiquitin-like protein-activating enzymelld:biogrid
cpath:CPATH-59047http://www.biopax.org/relea...FUNCTION: Catalytic subunit of the dimeric UBA3-ULA1 E1 enzyme. E1 activates NEDD8/RUB1 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBC12. PATHWAY: Protein modification; protein neddylation. SUBUNIT: Heterodimer of UBA3 and ULA1. Interacts with NEDD8 and UBC12 (By similarity). MISCELLANEOUS: Present with 752 molecules/cell in log phase SD medium. SIMILARITY: Belongs to the ubiquitin-activating E1 family. UBA3 subfamily. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.lld:biogrid
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