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| http://www.biopax.org/relea... | |
| http://www.biopax.org/relea... |
NEDD8-activating enzyme E1 catalytic subunit
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| http://www.biopax.org/relea... |
UBA3_YEAST
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| http://www.biopax.org/relea... | |
| http://www.biopax.org/relea... |
6.3.2.-,
RUB1-activating enzyme E1,
Ubiquitin-activating enzyme E1 3,
Ubiquitin-like protein-activating enzyme
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| http://www.biopax.org/relea... |
FUNCTION: Catalytic subunit of the dimeric UBA3-ULA1 E1 enzyme. E1 activates NEDD8/RUB1 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBC12. PATHWAY: Protein modification; protein neddylation. SUBUNIT: Heterodimer of UBA3 and ULA1. Interacts with NEDD8 and UBC12 (By similarity). MISCELLANEOUS: Present with 752 molecules/cell in log phase SD medium. SIMILARITY: Belongs to the ubiquitin-activating E1 family. UBA3 subfamily. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.
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