Linked Life Data

CPATH-57068

Source:http://cbio.mskcc.org/cpath#CPATH-57068

Statements in which the resource exists.
SubjectPredicateObjectContext
cpath:CPATH-57068rdf:typehttp://www.biopax.org/relea...lld:biogrid
cpath:CPATH-57068rdf:typehttp://www.biopax.org/relea...lld:cellmap
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cpath:CPATH-57068http://www.biopax.org/relea...Serine/threonine-protein kinase N2lld:biogrid
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cpath:CPATH-57068http://www.biopax.org/relea...FUNCTION: Exhibits a preference for highly basic protein substrates (By similarity). CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein. ENZYME REGULATION: Activated by lipids, particularly cardiolipin and to a lesser extent by other acidic phospholipids and unsaturated fatty acids. Two specific sites, Thr-816 (activation loop of the kinase domain) and Thr-958 (turn motif), need to be phosphorylated for its full activation (By similarity). SUBCELLULAR LOCATION: Cytoplasm (By similarity). DOMAIN: The C1 domain does not bind the diacylglycerol (DAG). PTM: Autophosphorylated. PTM: Activated by limited proteolysis with trypsin (By similarity). SIMILARITY: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. SIMILARITY: Contains 1 AGC-kinase C-terminal domain. SIMILARITY: Contains 1 C2 domain. SIMILARITY: Contains 1 protein kinase domain. SIMILARITY: Contains 3 REM (Hr1) repeats. GENE SYNONYMS: PRK2 PRKCL2. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.lld:biogrid
cpath:CPATH-57068http://www.biopax.org/relea...FUNCTION: Exhibits a preference for highly basic protein substrates (By similarity). CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein. ENZYME REGULATION: Activated by lipids, particularly cardiolipin and to a lesser extent by other acidic phospholipids and unsaturated fatty acids. Two specific sites, Thr-816 (activation loop of the kinase domain) and Thr-958 (turn motif), need to be phosphorylated for its full activation (By similarity). SUBCELLULAR LOCATION: Cytoplasm (By similarity). DOMAIN: The C1 domain does not bind the diacylglycerol (DAG). PTM: Autophosphorylated. PTM: Activated by limited proteolysis with trypsin (By similarity). SIMILARITY: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. SIMILARITY: Contains 1 AGC-kinase C-terminal domain. SIMILARITY: Contains 1 C2 domain. SIMILARITY: Contains 1 protein kinase domain. SIMILARITY: Contains 3 REM (Hr1) repeats. GENE SYNONYMS: PRK2 PRKCL2. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.lld:cellmap
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