| cpath:CPATH-57012 | rdf:type | http://www.biopax.org/relea... | lld:biogrid |
| cpath:CPATH-57012 | http://www.biopax.org/relea... | cpath:CPATH-LOCAL-232058 | lld:biogrid |
| cpath:CPATH-57012 | http://www.biopax.org/relea... | cpath:CPATH-LOCAL-232059 | lld:biogrid |
| cpath:CPATH-57012 | http://www.biopax.org/relea... | cpath:CPATH-LOCAL-232060 | lld:biogrid |
| cpath:CPATH-57012 | http://www.biopax.org/relea... | cpath:CPATH-LOCAL-232061 | lld:biogrid |
| cpath:CPATH-57012 | http://www.biopax.org/relea... | cpath:CPATH-LOCAL-232062 | lld:biogrid |
| cpath:CPATH-57012 | http://www.biopax.org/relea... | cpath:CPATH-LOCAL-232063 | lld:biogrid |
| cpath:CPATH-57012 | http://www.biopax.org/relea... | cpath:CPATH-LOCAL-232064 | lld:biogrid |
| cpath:CPATH-57012 | http://www.biopax.org/relea... | cpath:CPATH-LOCAL-232065 | lld:biogrid |
| cpath:CPATH-57012 | http://www.biopax.org/relea... | cpath:CPATH-LOCAL-232066 | lld:biogrid |
| cpath:CPATH-57012 | http://www.biopax.org/relea... | cpath:CPATH-LOCAL-232067 | lld:biogrid |
| cpath:CPATH-57012 | http://www.biopax.org/relea... | cpath:CPATH-LOCAL-232068 | lld:biogrid |
| cpath:CPATH-57012 | http://www.biopax.org/relea... | cpath:CPATH-LOCAL-232069 | lld:biogrid |
| cpath:CPATH-57012 | http://www.biopax.org/relea... | cpath:CPATH-LOCAL-232070 | lld:biogrid |
| cpath:CPATH-57012 | http://www.biopax.org/relea... | cpath:CPATH-LOCAL-241707 | lld:biogrid |
| cpath:CPATH-57012 | http://www.biopax.org/relea... | Tyrosine-protein phosphatase non-receptor type 22 | lld:biogrid |
| cpath:CPATH-57012 | http://www.biopax.org/relea... | PTN22_HUMAN | lld:biogrid |
| cpath:CPATH-57012 | http://www.biopax.org/relea... | cpath:CPATH-LOCAL-232071 | lld:biogrid |
| cpath:CPATH-57012 | http://www.biopax.org/relea... | 3.1.3.48 | lld:biogrid |
| cpath:CPATH-57012 | http://www.biopax.org/relea... | Lymphoid phosphatase | lld:biogrid |
| cpath:CPATH-57012 | http://www.biopax.org/relea... | Hematopoietic cell protein-tyrosine phosphatase 70Z-PEP | lld:biogrid |
| cpath:CPATH-57012 | http://www.biopax.org/relea... | LyP | lld:biogrid |
| cpath:CPATH-57012 | http://www.biopax.org/relea... | FUNCTION: Seems to act on Cbl. May play a role in regulating the function of Cbl and its associated protein kinases. Acts as negative regulator of T cell receptor (TCR) signaling. Dephosphorylates and inactivates the SRC family kinases. CATALYTIC ACTIVITY: Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate. ENZYME REGULATION: Down-regulated by phosphorylation. SUBCELLULAR LOCATION: Cytoplasm (By similarity). ALTERNATIVE PRODUCTS: Event=Alternative splicing; Named isoforms=5; Name=1; Synonyms=LyP1; IsoId=Q9Y2R2-1; Sequence=Displayed; Name=2; Synonyms=LyP2; IsoId=Q9Y2R2-2; Sequence=VSP_005134; Note=Due to intron retention; Name=3; IsoId=Q9Y2R2-3; Sequence=VSP_039728; Note=No experimental confirmation available; Name=4; Synonyms=LYP3; IsoId=Q9Y2R2-4; Sequence=VSP_039729; Note=No experimental confirmation available; Name=5; IsoId=Q9Y2R2-5; Sequence=VSP_039725, VSP_039726, VSP_039727; Note=No experimental confirmation available; TISSUE SPECIFICITY: Predominantly expressed in lymphoid tissues and cells. Isoform 1 is expressed in thymocytes and both mature B and T-cells. PTM: Phosphorylation on Ser-35 by PKC/PRKCD abrogates its ability to dephosphorylate and inactivate the SRC family kinases. SIMILARITY: Belongs to the protein-tyrosine phosphatase family. Non-receptor class 4 subfamily. SIMILARITY: Contains 1 tyrosine-protein phosphatase domain. GENE SYNONYMS: PTPN8. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License. | lld:biogrid |
| cpath:CPATH-57012 | skos:exactMatch | uniprot-protein:Q9Y2R2 | lld:mappings |
| cpath:CPATH-57012 | skos:closeMatch | entrez-gene:26191 | lld:mappings |
| cpath:CPATH-LOCAL-11791179 | http://www.biopax.org/relea... | cpath:CPATH-57012 | lld:biogrid |
