| Predicate | Object |
|---|---|
| rdf:type | |
| http://www.biopax.org/relea... |
cpath:CPATH-LOCAL-232058,
cpath:CPATH-LOCAL-232059,
cpath:CPATH-LOCAL-232060,
cpath:CPATH-LOCAL-232061,
cpath:CPATH-LOCAL-232062,
cpath:CPATH-LOCAL-232063,
cpath:CPATH-LOCAL-232064,
cpath:CPATH-LOCAL-232065,
cpath:CPATH-LOCAL-232066,
cpath:CPATH-LOCAL-232067,
cpath:CPATH-LOCAL-232068,
cpath:CPATH-LOCAL-232069,
cpath:CPATH-LOCAL-232070,
cpath:CPATH-LOCAL-241707
|
| http://www.biopax.org/relea... |
Tyrosine-protein phosphatase non-receptor type 22
|
| http://www.biopax.org/relea... |
PTN22_HUMAN
|
| http://www.biopax.org/relea... | |
| http://www.biopax.org/relea... |
3.1.3.48,
Hematopoietic cell protein-tyrosine phosphatase 70Z-PEP,
LyP,
Lymphoid phosphatase
|
| http://www.biopax.org/relea... |
FUNCTION: Seems to act on Cbl. May play a role in regulating the function of Cbl and its associated protein kinases. Acts as negative regulator of T cell receptor (TCR) signaling. Dephosphorylates and inactivates the SRC family kinases. CATALYTIC ACTIVITY: Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate. ENZYME REGULATION: Down-regulated by phosphorylation. SUBCELLULAR LOCATION: Cytoplasm (By similarity). ALTERNATIVE PRODUCTS: Event=Alternative splicing; Named isoforms=5; Name=1; Synonyms=LyP1; IsoId=Q9Y2R2-1; Sequence=Displayed; Name=2; Synonyms=LyP2; IsoId=Q9Y2R2-2; Sequence=VSP_005134; Note=Due to intron retention; Name=3; IsoId=Q9Y2R2-3; Sequence=VSP_039728; Note=No experimental confirmation available; Name=4; Synonyms=LYP3; IsoId=Q9Y2R2-4; Sequence=VSP_039729; Note=No experimental confirmation available; Name=5; IsoId=Q9Y2R2-5; Sequence=VSP_039725, VSP_039726, VSP_039727; Note=No experimental confirmation available; TISSUE SPECIFICITY: Predominantly expressed in lymphoid tissues and cells. Isoform 1 is expressed in thymocytes and both mature B and T-cells. PTM: Phosphorylation on Ser-35 by PKC/PRKCD abrogates its ability to dephosphorylate and inactivate the SRC family kinases. SIMILARITY: Belongs to the protein-tyrosine phosphatase family. Non-receptor class 4 subfamily. SIMILARITY: Contains 1 tyrosine-protein phosphatase domain. GENE SYNONYMS: PTPN8. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.
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