Linked Life Data

CPATH-5512

Source:http://cbio.mskcc.org/cpath#CPATH-5512

Statements in which the resource exists.
SubjectPredicateObjectContext
cpath:CPATH-5512rdf:typehttp://www.biopax.org/relea...lld:biogrid
cpath:CPATH-5512http://www.biopax.org/relea...cpath:CPATH-LOCAL-24358lld:biogrid
cpath:CPATH-5512http://www.biopax.org/relea...cpath:CPATH-LOCAL-24359lld:biogrid
cpath:CPATH-5512http://www.biopax.org/relea...cpath:CPATH-LOCAL-24360lld:biogrid
cpath:CPATH-5512http://www.biopax.org/relea...cpath:CPATH-LOCAL-24361lld:biogrid
cpath:CPATH-5512http://www.biopax.org/relea...cpath:CPATH-LOCAL-24362lld:biogrid
cpath:CPATH-5512http://www.biopax.org/relea...cpath:CPATH-LOCAL-24363lld:biogrid
cpath:CPATH-5512http://www.biopax.org/relea...cpath:CPATH-LOCAL-24364lld:biogrid
cpath:CPATH-5512http://www.biopax.org/relea...cpath:CPATH-LOCAL-24365lld:biogrid
cpath:CPATH-5512http://www.biopax.org/relea...cpath:CPATH-LOCAL-24366lld:biogrid
cpath:CPATH-5512http://www.biopax.org/relea...cpath:CPATH-LOCAL-24367lld:biogrid
cpath:CPATH-5512http://www.biopax.org/relea...cpath:CPATH-LOCAL-27286lld:biogrid
cpath:CPATH-5512http://www.biopax.org/relea...Interferon alpha/beta receptor 1lld:biogrid
cpath:CPATH-5512http://www.biopax.org/relea...INAR1_HUMANlld:biogrid
cpath:CPATH-5512http://www.biopax.org/relea...cpath:CPATH-LOCAL-24356lld:biogrid
cpath:CPATH-5512http://www.biopax.org/relea...Cytokine receptor class-II member 1lld:biogrid
cpath:CPATH-5512http://www.biopax.org/relea...IFN-R-1lld:biogrid
cpath:CPATH-5512http://www.biopax.org/relea...IFN-alpha/beta receptor 1lld:biogrid
cpath:CPATH-5512http://www.biopax.org/relea...CRF2-1lld:biogrid
cpath:CPATH-5512http://www.biopax.org/relea...Type I interferon receptor 1lld:biogrid
cpath:CPATH-5512http://www.biopax.org/relea...Cytokine receptor family 2 member 1lld:biogrid
cpath:CPATH-5512http://www.biopax.org/relea...FUNCTION: Associates with IFNAR2 to form the type I interferon receptor. Receptor for interferons alpha and beta. Binding to type I IFNs triggers tyrosine phosphorylation of a number of proteins including JAKs, TYK2, STAT proteins and IFNR alpha- and beta- subunits themselves. SUBUNIT: Heterodimer with IFNAR2; in presence of interferon alpha and beta ligands, the heterodimer forms the type I interferon receptor. Interacts with STAT1 and STAT2; the interaction requires its phosphorylation at Tyr-466. Interacts with IFNAR2. SUBCELLULAR LOCATION: Isoform 1: Membrane; Single-pass type I membrane protein. ALTERNATIVE PRODUCTS: Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=P17181-1; Sequence=Displayed; Name=2; Synonyms=Sol-1, Soluble form 1; IsoId=P17181-2; Sequence=VSP_029930, VSP_029931; Note=Incomplete sequence; Name=3; Synonyms=Sol-2, Soluble form 2; IsoId=P17181-3; Sequence=VSP_029928, VSP_029929; Note=Incomplete sequence; TISSUE SPECIFICITY: IFN receptors are present in all tissues and even on the surface of most IFN-resistant cells. Isoform 1, isoform 2 and isoform 3 are expressed in the IFN-alpha sensitive myeloma cell line U266S. Isoform 2 and isoform 3 are expressed in the IFN-alpha resistant myeloma cell line U266R. Isoform 1 is not expressed in IFN-alpha resistant myeloma cell line U266R. PTM: Phosphorylated on tyrosine residues by TYK2 tyrosine kinase. SIMILARITY: Belongs to the type II cytokine receptor family. SIMILARITY: Contains 3 fibronectin type-III domains. SEQUENCE CAUTION: Sequence=AAH02590.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence; WEB RESOURCE: Name=SeattleSNPs; URL="http://pga.gs.washington.edu/data/ifnar1/"; GENE SYNONYMS: IFNAR. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.lld:biogrid
cpath:CPATH-5512skos:exactMatchuniprot-protein:P17181lld:mappings
cpath:CPATH-5512skos:closeMatchentrez-gene:3454lld:mappings
cpath:CPATH-LOCAL-10937304http://www.biopax.org/relea...cpath:CPATH-5512lld:biogrid
cpath:CPATH-LOCAL-11006095http://www.biopax.org/relea...cpath:CPATH-5512lld:biogrid
cpath:CPATH-LOCAL-11056195http://www.biopax.org/relea...cpath:CPATH-5512lld:biogrid
cpath:CPATH-LOCAL-11085055http://www.biopax.org/relea...cpath:CPATH-5512lld:biogrid
cpath:CPATH-LOCAL-11104315http://www.biopax.org/relea...cpath:CPATH-5512lld:biogrid
cpath:CPATH-LOCAL-11108650http://www.biopax.org/relea...cpath:CPATH-5512lld:biogrid
cpath:CPATH-LOCAL-11191389http://www.biopax.org/relea...cpath:CPATH-5512lld:biogrid
cpath:CPATH-LOCAL-11215495http://www.biopax.org/relea...cpath:CPATH-5512lld:biogrid
cpath:CPATH-LOCAL-11258770http://www.biopax.org/relea...cpath:CPATH-5512lld:biogrid
cpath:CPATH-LOCAL-11276424http://www.biopax.org/relea...cpath:CPATH-5512lld:biogrid
cpath:CPATH-LOCAL-11391159http://www.biopax.org/relea...cpath:CPATH-5512lld:biogrid
cpath:CPATH-LOCAL-11393634http://www.biopax.org/relea...cpath:CPATH-5512lld:biogrid
cpath:CPATH-LOCAL-11625969http://www.biopax.org/relea...cpath:CPATH-5512lld:biogrid
cpath:CPATH-LOCAL-11671150http://www.biopax.org/relea...cpath:CPATH-5512lld:biogrid
cpath:CPATH-LOCAL-11700609http://www.biopax.org/relea...cpath:CPATH-5512lld:biogrid
cpath:CPATH-LOCAL-11725225http://www.biopax.org/relea...cpath:CPATH-5512lld:biogrid
cpath:CPATH-LOCAL-11755915http://www.biopax.org/relea...cpath:CPATH-5512lld:biogrid
cpath:CPATH-LOCAL-11769400http://www.biopax.org/relea...cpath:CPATH-5512lld:biogrid
cpath:CPATH-LOCAL-11800780http://www.biopax.org/relea...cpath:CPATH-5512lld:biogrid
cpath:CPATH-LOCAL-11811805http://www.biopax.org/relea...cpath:CPATH-5512lld:biogrid
cpath:CPATH-LOCAL-11828110http://www.biopax.org/relea...cpath:CPATH-5512lld:biogrid