| Predicate | Object |
|---|---|
| rdf:type | |
| http://www.biopax.org/relea... | |
| http://www.biopax.org/relea... |
Interferon alpha/beta receptor 1
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| http://www.biopax.org/relea... |
INAR1_HUMAN
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| http://www.biopax.org/relea... | |
| http://www.biopax.org/relea... |
CRF2-1,
Cytokine receptor class-II member 1,
Cytokine receptor family 2 member 1,
IFN-R-1,
IFN-alpha/beta receptor 1,
Type I interferon receptor 1
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| http://www.biopax.org/relea... |
FUNCTION: Associates with IFNAR2 to form the type I interferon receptor. Receptor for interferons alpha and beta. Binding to type I IFNs triggers tyrosine phosphorylation of a number of proteins including JAKs, TYK2, STAT proteins and IFNR alpha- and beta- subunits themselves. SUBUNIT: Heterodimer with IFNAR2; in presence of interferon alpha and beta ligands, the heterodimer forms the type I interferon receptor. Interacts with STAT1 and STAT2; the interaction requires its phosphorylation at Tyr-466. Interacts with IFNAR2. SUBCELLULAR LOCATION: Isoform 1: Membrane; Single-pass type I membrane protein. ALTERNATIVE PRODUCTS: Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=P17181-1; Sequence=Displayed; Name=2; Synonyms=Sol-1, Soluble form 1; IsoId=P17181-2; Sequence=VSP_029930, VSP_029931; Note=Incomplete sequence; Name=3; Synonyms=Sol-2, Soluble form 2; IsoId=P17181-3; Sequence=VSP_029928, VSP_029929; Note=Incomplete sequence; TISSUE SPECIFICITY: IFN receptors are present in all tissues and even on the surface of most IFN-resistant cells. Isoform 1, isoform 2 and isoform 3 are expressed in the IFN-alpha sensitive myeloma cell line U266S. Isoform 2 and isoform 3 are expressed in the IFN-alpha resistant myeloma cell line U266R. Isoform 1 is not expressed in IFN-alpha resistant myeloma cell line U266R. PTM: Phosphorylated on tyrosine residues by TYK2 tyrosine kinase. SIMILARITY: Belongs to the type II cytokine receptor family. SIMILARITY: Contains 3 fibronectin type-III domains. SEQUENCE CAUTION: Sequence=AAH02590.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence; WEB RESOURCE: Name=SeattleSNPs; URL="http://pga.gs.washington.edu/data/ifnar1/"; GENE SYNONYMS: IFNAR. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.
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