Linked Life Data

CPATH-49149

Source:http://cbio.mskcc.org/cpath#CPATH-49149

Statements in which the resource exists.
SubjectPredicateObjectContext
cpath:CPATH-49149rdf:typehttp://www.biopax.org/relea...lld:biogrid
cpath:CPATH-49149rdf:typehttp://www.biopax.org/relea...lld:cellmap
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cpath:CPATH-49149http://www.biopax.org/relea...Ras-related C3 botulinum toxin substrate 3lld:biogrid
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cpath:CPATH-49149http://www.biopax.org/relea...FUNCTION: Plasma membrane-associated small GTPase which cycles between an active GTP-bound and inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses, such as cell spreading and the formation of actin-based protusions including lamellipodia and membrane ruffles. SUBUNIT: Interacts with the GEF protein DOCK7, which promotes the exchange between GDP and GTP, and therefore activates it. Interacts with C1D. SUBCELLULAR LOCATION: Cytoplasm. Endomembrane system. Cell projection, lamellipodium. Note=Membrane-associated when activated. Co-localizes with NRBP to endomembranes and at the cell periphery in lamellipodia. TISSUE SPECIFICITY: Highest levels in brain, also detected in heart, placenta and pancreas. INDUCTION: Expression down-regulated in quiescent fibroblasts and clearly induced by serum stimulation. SIMILARITY: Belongs to the small GTPase superfamily. Rho family. WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/RAC3ID42022ch17q25.html"; COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.lld:biogrid
cpath:CPATH-49149http://www.biopax.org/relea...FUNCTION: Plasma membrane-associated small GTPase which cycles between an active GTP-bound and inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses, such as cell spreading and the formation of actin-based protusions including lamellipodia and membrane ruffles. SUBUNIT: Interacts with the GEF protein DOCK7, which promotes the exchange between GDP and GTP, and therefore activates it. Interacts with C1D. SUBCELLULAR LOCATION: Cytoplasm. Endomembrane system. Cell projection, lamellipodium. Note=Membrane-associated when activated. Co-localizes with NRBP to endomembranes and at the cell periphery in lamellipodia. TISSUE SPECIFICITY: Highest levels in brain, also detected in heart, placenta and pancreas. INDUCTION: Expression down-regulated in quiescent fibroblasts and clearly induced by serum stimulation. SIMILARITY: Belongs to the small GTPase superfamily. Rho family. WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/RAC3ID42022ch17q25.html"; COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.lld:cellmap
cpath:CPATH-49149skos:exactMatchuniprot-protein:P60763lld:mappings
cpath:CPATH-49149skos:closeMatchentrez-gene:5881lld:mappings
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cpath:CPATH-LOCAL-11049129http://www.biopax.org/relea...cpath:CPATH-49149lld:biogrid
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cpath:CPATH-LOCAL-11345980http://www.biopax.org/relea...cpath:CPATH-49149lld:biogrid
cpath:CPATH-LOCAL-11917000http://www.biopax.org/relea...cpath:CPATH-49149lld:biogrid
cpath:CPATH-LOCAL-11921904http://www.biopax.org/relea...cpath:CPATH-49149lld:biogrid
cpath:CPATH-LOCAL-7749147http://www.biopax.org/relea...cpath:CPATH-49149lld:cellmap