| Predicate | Object |
|---|---|
| rdf:type | |
| http://www.biopax.org/relea... |
cpath:CPATH-LOCAL-196740,
cpath:CPATH-LOCAL-196740,
cpath:CPATH-LOCAL-196741,
cpath:CPATH-LOCAL-196741,
cpath:CPATH-LOCAL-196742,
cpath:CPATH-LOCAL-196742,
cpath:CPATH-LOCAL-196743,
cpath:CPATH-LOCAL-196743,
cpath:CPATH-LOCAL-196744,
cpath:CPATH-LOCAL-196744,
cpath:CPATH-LOCAL-196745,
cpath:CPATH-LOCAL-196745,
cpath:CPATH-LOCAL-205902,
cpath:CPATH-LOCAL-205902
|
| http://www.biopax.org/relea... |
Ras-related C3 botulinum toxin substrate 3,
Ras-related C3 botulinum toxin substrate 3
|
| http://www.biopax.org/relea... |
RAC3_HUMAN,
RAC3_HUMAN
|
| http://www.biopax.org/relea... | |
| http://www.biopax.org/relea... |
p21-Rac3,
p21-Rac3
|
| http://www.biopax.org/relea... |
FUNCTION: Plasma membrane-associated small GTPase which cycles between an active GTP-bound and inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses, such as cell spreading and the formation of actin-based protusions including lamellipodia and membrane ruffles. SUBUNIT: Interacts with the GEF protein DOCK7, which promotes the exchange between GDP and GTP, and therefore activates it. Interacts with C1D. SUBCELLULAR LOCATION: Cytoplasm. Endomembrane system. Cell projection, lamellipodium. Note=Membrane-associated when activated. Co-localizes with NRBP to endomembranes and at the cell periphery in lamellipodia. TISSUE SPECIFICITY: Highest levels in brain, also detected in heart, placenta and pancreas. INDUCTION: Expression down-regulated in quiescent fibroblasts and clearly induced by serum stimulation. SIMILARITY: Belongs to the small GTPase superfamily. Rho family. WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/RAC3ID42022ch17q25.html"; COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.,
FUNCTION: Plasma membrane-associated small GTPase which cycles between an active GTP-bound and inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses, such as cell spreading and the formation of actin-based protusions including lamellipodia and membrane ruffles. SUBUNIT: Interacts with the GEF protein DOCK7, which promotes the exchange between GDP and GTP, and therefore activates it. Interacts with C1D. SUBCELLULAR LOCATION: Cytoplasm. Endomembrane system. Cell projection, lamellipodium. Note=Membrane-associated when activated. Co-localizes with NRBP to endomembranes and at the cell periphery in lamellipodia. TISSUE SPECIFICITY: Highest levels in brain, also detected in heart, placenta and pancreas. INDUCTION: Expression down-regulated in quiescent fibroblasts and clearly induced by serum stimulation. SIMILARITY: Belongs to the small GTPase superfamily. Rho family. WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/RAC3ID42022ch17q25.html"; COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.
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| skos:exactMatch | |
| skos:closeMatch |