Linked Life Data

CPATH-47710

Source:http://cbio.mskcc.org/cpath#CPATH-47710

Statements in which the resource exists.
SubjectPredicateObjectContext
cpath:CPATH-47710rdf:typehttp://www.biopax.org/relea...lld:biogrid
cpath:CPATH-47710http://www.biopax.org/relea...cpath:CPATH-LOCAL-190585lld:biogrid
cpath:CPATH-47710http://www.biopax.org/relea...cpath:CPATH-LOCAL-190586lld:biogrid
cpath:CPATH-47710http://www.biopax.org/relea...cpath:CPATH-LOCAL-190587lld:biogrid
cpath:CPATH-47710http://www.biopax.org/relea...cpath:CPATH-LOCAL-190588lld:biogrid
cpath:CPATH-47710http://www.biopax.org/relea...cpath:CPATH-LOCAL-195662lld:biogrid
cpath:CPATH-47710http://www.biopax.org/relea...Homologous-pairing protein 2 homologlld:biogrid
cpath:CPATH-47710http://www.biopax.org/relea...HOP2_RATlld:biogrid
cpath:CPATH-47710http://www.biopax.org/relea...cpath:CPATH-LOCAL-190583lld:biogrid
cpath:CPATH-47710http://www.biopax.org/relea...PSMC3-interacting proteinlld:biogrid
cpath:CPATH-47710http://www.biopax.org/relea...Nuclear receptor coactivator GT198lld:biogrid
cpath:CPATH-47710http://www.biopax.org/relea...Proteasome 26S ATPase subunit 3-interacting proteinlld:biogrid
cpath:CPATH-47710http://www.biopax.org/relea...FUNCTION: Plays an important role in meiotic recombination. Stimulates DMC1-mediated strand exchange required for pairing homologous chromosomes during meiosis. The complex PSMC3IP/MND1 binds DNA, stimulates the recombinase activity of DMC1 as well as DMC1 D-loop formation from double-strand DNA. This complex stabilizes presynaptic RAD51 and DMC1 filaments formed on single strand DNA to capture double-strand DNA. This complex stimulates both synaptic and presynaptic critical steps in RAD51 and DMC1- promoted homologous pairing. May inhibit HIV-1 viral protein TAT activity and modulate the activity of proteasomes through association with PSMC3 (By similarity). Plays a role as a coactivator in nuclear receptor-mediated transcription. SUBUNIT: Forms a stable heterodimer with MND1. Interacts with PSMC3/TBP1 (By similarity). Interacts with the DNA-binding domain of the nuclear receptors NR3C1/GR, ESR2/ER-beta, THRB and RXRA. SUBCELLULAR LOCATION: Nucleus (By similarity). PTM: Phosphorylated by PKA, PKC and MAPK. SIMILARITY: Belongs to the HOP2 family. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.lld:biogrid
cpath:CPATH-47710skos:exactMatchuniprot-protein:Q91ZY6lld:mappings
cpath:CPATH-47710skos:closeMatchentrez-gene:140938lld:mappings
cpath:CPATH-LOCAL-7827702http://www.biopax.org/relea...cpath:CPATH-47710lld:biogrid
cpath:CPATH-LOCAL-7830927http://www.biopax.org/relea...cpath:CPATH-47710lld:biogrid
cpath:CPATH-LOCAL-11139369http://www.biopax.org/relea...cpath:CPATH-47710lld:biogrid
cpath:CPATH-LOCAL-11353375http://www.biopax.org/relea...cpath:CPATH-47710lld:biogrid