| Predicate | Object |
|---|---|
| rdf:type | |
| http://www.biopax.org/relea... | |
| http://www.biopax.org/relea... |
Homologous-pairing protein 2 homolog
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| http://www.biopax.org/relea... |
HOP2_RAT
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| http://www.biopax.org/relea... | |
| http://www.biopax.org/relea... |
Nuclear receptor coactivator GT198,
PSMC3-interacting protein,
Proteasome 26S ATPase subunit 3-interacting protein
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| http://www.biopax.org/relea... |
FUNCTION: Plays an important role in meiotic recombination. Stimulates DMC1-mediated strand exchange required for pairing homologous chromosomes during meiosis. The complex PSMC3IP/MND1 binds DNA, stimulates the recombinase activity of DMC1 as well as DMC1 D-loop formation from double-strand DNA. This complex stabilizes presynaptic RAD51 and DMC1 filaments formed on single strand DNA to capture double-strand DNA. This complex stimulates both synaptic and presynaptic critical steps in RAD51 and DMC1- promoted homologous pairing. May inhibit HIV-1 viral protein TAT activity and modulate the activity of proteasomes through association with PSMC3 (By similarity). Plays a role as a coactivator in nuclear receptor-mediated transcription. SUBUNIT: Forms a stable heterodimer with MND1. Interacts with PSMC3/TBP1 (By similarity). Interacts with the DNA-binding domain of the nuclear receptors NR3C1/GR, ESR2/ER-beta, THRB and RXRA. SUBCELLULAR LOCATION: Nucleus (By similarity). PTM: Phosphorylated by PKA, PKC and MAPK. SIMILARITY: Belongs to the HOP2 family. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.
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