| Predicate | Object |
|---|---|
| rdf:type | |
| http://www.biopax.org/relea... | |
| http://www.biopax.org/relea... |
Ceramide synthase 1
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| http://www.biopax.org/relea... |
CERS1_HUMAN
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| http://www.biopax.org/relea... | |
| http://www.biopax.org/relea... |
CerS1,
LAG1 longevity assurance homolog 1,
Longevity assurance gene 1 protein homolog 1,
Protein UOG-1
|
| http://www.biopax.org/relea... |
FUNCTION: May be either a bona fide (dihydro)ceramide synthase or a modulator of its activity. When overexpressed in cells is involved in the production of sphingolipids containing mainly one fatty acid donor (N-linked stearoyl- (C18) ceramide) in a fumonisin B1-independent manner (By similarity). SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity). SUBCELLULAR LOCATION: Isoform 1: Endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity). Golgi apparatus membrane; Multi-pass membrane protein (By similarity). Note=Isoform 1 may recycle from the Golgi to the endoplasmic reticulum. ALTERNATIVE PRODUCTS: Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P27544-1; Sequence=Displayed; Name=2; IsoId=P27544-2; Sequence=VSP_003049; Note=No experimental confirmation available; MISCELLANEOUS: This protein is produced by a bicistronic gene which also produces the GDF1 protein from a non-overlapping reading frame. SIMILARITY: Contains 1 TLC (TRAM/LAG1/CLN8) domain. GENE SYNONYMS: LAG1 LASS1 UOG1. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.
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