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| http://www.biopax.org/relea... | |
| http://www.biopax.org/relea... |
Probable ATP-dependent RNA helicase DDX6
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| http://www.biopax.org/relea... |
DDX6_HUMAN
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| http://www.biopax.org/relea... | |
| http://www.biopax.org/relea... |
3.6.4.13,
ATP-dependent RNA helicase p54,
DEAD box protein 6,
Oncogene RCK
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| http://www.biopax.org/relea... |
FUNCTION: In the process of mRNA degradation, may play a role in mRNA decapping. CATALYTIC ACTIVITY: ATP + H(2)O = ADP + phosphate. SUBUNIT: Forms a complex with DCP1A, DCP2, EDC3 and EDC4/HEDLS. SUBCELLULAR LOCATION: Cytoplasm, P-body. Note=Processing bodies (PB). TISSUE SPECIFICITY: Abundantly expressed in most tissues. PTM: Phosphorylated upon DNA damage, probably by ATM or ATR. DISEASE: Note=A chromosomal aberration involving DDX6 may be a cause of hematopoietic tumors such as B-cell lymphomas. Translocation t(11;14)(q23;q32). SIMILARITY: Belongs to the DEAD box helicase family. DDX6/DHH1 subfamily. SIMILARITY: Contains 1 helicase ATP-binding domain. SIMILARITY: Contains 1 helicase C-terminal domain. GENE SYNONYMS: HLR2 RCK. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.
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