| Predicate | Object |
|---|---|
| rdf:type | |
| http://www.biopax.org/relea... | |
| http://www.biopax.org/relea... |
High affinity immunoglobulin gamma Fc receptor I
|
| http://www.biopax.org/relea... |
FCGR1_HUMAN
|
| http://www.biopax.org/relea... | |
| http://www.biopax.org/relea... |
CD64,
Fc-gamma RI,
Fc-gamma RIA,
FcRI,
FcgammaRIa,
IgG Fc receptor I
|
| http://www.biopax.org/relea... |
FUNCTION: High affinity receptor for the Fc region of immunoglobulins gamma. Functions in both innate and adaptive immune responses. SUBUNIT: Interacts with FCERG1; forms a functional signaling complex. Interacts with FLNA; prevents FCGR1A degradation. Interacts with EPB41L2, LAT and PPL. SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein. Note=Stabilized at the cell membrane through interaction with FCER1G. ALTERNATIVE PRODUCTS: Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=A; IsoId=P12314-1; Sequence=Displayed; Name=2; Synonyms=B; IsoId=P12314-2; Sequence=VSP_002637; TISSUE SPECIFICITY: Monocyte/macrophage specific. PTM: Phosphorylated on serine residues (By similarity). SIMILARITY: Belongs to the immunoglobulin superfamily. FCGR1 family. SIMILARITY: Contains 3 Ig-like C2-type (immunoglobulin-like) domains. WEB RESOURCE: Name=FCGR1Abase; Note=FCGR1A mutation db; URL="http://bioinf.uta.fi/FCGR1Abase/"; GENE SYNONYMS: FCG1 FCGR1 IGFR1. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.
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