Linked Life Data

CPATH-145411

Source:http://cbio.mskcc.org/cpath#CPATH-145411

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SubjectPredicateObjectContext
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cpath:CPATH-145411http://www.biopax.org/relea...cpath:CPATH-LOCAL-608188lld:biogrid
cpath:CPATH-145411http://www.biopax.org/relea...Heparin cofactor 2lld:biogrid
cpath:CPATH-145411http://www.biopax.org/relea...HEP2_HUMANlld:biogrid
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cpath:CPATH-145411http://www.biopax.org/relea...Heparin cofactor IIlld:biogrid
cpath:CPATH-145411http://www.biopax.org/relea...HC-IIlld:biogrid
cpath:CPATH-145411http://www.biopax.org/relea...HLS2lld:biogrid
cpath:CPATH-145411http://www.biopax.org/relea...Serpin D1lld:biogrid
cpath:CPATH-145411http://www.biopax.org/relea...Protease inhibitor leuserpin-2lld:biogrid
cpath:CPATH-145411http://www.biopax.org/relea...FUNCTION: Thrombin inhibitor activated by the glycosaminoglycans, heparin or dermatan sulfate. In the presence of the latter, HC-II becomes the predominant thrombin inhibitor in place of antithrombin III (AT-III). Also inhibits chymotrypsin, but in a glycosaminoglycan-independent manner. FUNCTION: Peptides at the N-terminal of HC-II have chemotactic activity for both monocytes and neutrophils. TISSUE SPECIFICITY: Expressed predominantly in liver. Also present in plasma. DOMAIN: The N-terminal acidic repeat region mediates, in part, the glycosaminoglycan-accelerated thrombin inhibition. PTM: Phosphorylation sites are present in the extracelllular medium. DISEASE: Defects in SERPIND1 are the cause of heparin cofactor 2 deficiency (HCF2D) [MIM:612356]. HCF2D is an important risk factor for hereditary thrombophilia, a hemostatic disorder characterized by a tendency to recurrent thrombosis. SIMILARITY: Belongs to the serpin family. SEQUENCE CAUTION: Sequence=CAG30459.1; Type=Erroneous initiation; GENE SYNONYMS: HCF2. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.lld:biogrid
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