| Predicate | Object |
|---|---|
| rdf:type | |
| http://www.biopax.org/relea... | |
| http://www.biopax.org/relea... |
Heparin cofactor 2
|
| http://www.biopax.org/relea... |
HEP2_HUMAN
|
| http://www.biopax.org/relea... | |
| http://www.biopax.org/relea... |
HC-II,
HLS2,
Heparin cofactor II,
Protease inhibitor leuserpin-2,
Serpin D1
|
| http://www.biopax.org/relea... |
FUNCTION: Thrombin inhibitor activated by the glycosaminoglycans, heparin or dermatan sulfate. In the presence of the latter, HC-II becomes the predominant thrombin inhibitor in place of antithrombin III (AT-III). Also inhibits chymotrypsin, but in a glycosaminoglycan-independent manner. FUNCTION: Peptides at the N-terminal of HC-II have chemotactic activity for both monocytes and neutrophils. TISSUE SPECIFICITY: Expressed predominantly in liver. Also present in plasma. DOMAIN: The N-terminal acidic repeat region mediates, in part, the glycosaminoglycan-accelerated thrombin inhibition. PTM: Phosphorylation sites are present in the extracelllular medium. DISEASE: Defects in SERPIND1 are the cause of heparin cofactor 2 deficiency (HCF2D) [MIM:612356]. HCF2D is an important risk factor for hereditary thrombophilia, a hemostatic disorder characterized by a tendency to recurrent thrombosis. SIMILARITY: Belongs to the serpin family. SEQUENCE CAUTION: Sequence=CAG30459.1; Type=Erroneous initiation; GENE SYNONYMS: HCF2. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.
|
| skos:exactMatch |