Linked Life Data

CPATH-132201

Source:http://cbio.mskcc.org/cpath#CPATH-132201

Statements in which the resource exists.
SubjectPredicateObjectContext
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cpath:CPATH-132201http://www.biopax.org/relea...cpath:CPATH-LOCAL-547991lld:biogrid
cpath:CPATH-132201http://www.biopax.org/relea...Atrial natriuretic peptide receptor 1lld:biogrid
cpath:CPATH-132201http://www.biopax.org/relea...ANPRA_MOUSElld:biogrid
cpath:CPATH-132201http://www.biopax.org/relea...cpath:CPATH-LOCAL-544728lld:biogrid
cpath:CPATH-132201http://www.biopax.org/relea...GC-Alld:biogrid
cpath:CPATH-132201http://www.biopax.org/relea...Atrial natriuretic peptide receptor type Alld:biogrid
cpath:CPATH-132201http://www.biopax.org/relea...Guanylate cyclase Alld:biogrid
cpath:CPATH-132201http://www.biopax.org/relea...ANPR-Alld:biogrid
cpath:CPATH-132201http://www.biopax.org/relea...4.6.1.2lld:biogrid
cpath:CPATH-132201http://www.biopax.org/relea...NPR-Alld:biogrid
cpath:CPATH-132201http://www.biopax.org/relea...ANP-Alld:biogrid
cpath:CPATH-132201http://www.biopax.org/relea...FUNCTION: Receptor for the atrial natriuretic peptide NPPA/ANP and the brain natriuretic peptide NPPB/BNP which are potent vasoactive hormones playing a key role in cardiovascular homeostasis. Has guanylate cyclase activity upon binding of the ligand. CATALYTIC ACTIVITY: GTP = 3',5'-cyclic GMP + diphosphate. SUBUNIT: Homodimer (By similarity). SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein. PTM: Phosphorylation of the protein kinase-like domain is required for full activation by ANP (By similarity). DISRUPTION PHENOTYPE: Mice display systemic hypertension associated with cardiac hypertrophy and ventricular enlargement. SIMILARITY: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. SIMILARITY: Contains 1 guanylate cyclase domain. SIMILARITY: Contains 1 protein kinase domain. GENE SYNONYMS: Npra. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.lld:biogrid
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cpath:CPATH-132201skos:closeMatchentrez-gene:18160lld:mappings
cpath:CPATH-LOCAL-10482955http://www.biopax.org/relea...cpath:CPATH-132201lld:biogrid
cpath:CPATH-LOCAL-10507315http://www.biopax.org/relea...cpath:CPATH-132201lld:biogrid
cpath:CPATH-LOCAL-10514005http://www.biopax.org/relea...cpath:CPATH-132201lld:biogrid