| Predicate | Object |
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| http://www.biopax.org/relea... | |
| http://www.biopax.org/relea... |
Atrial natriuretic peptide receptor 1
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| http://www.biopax.org/relea... |
ANPRA_MOUSE
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| http://www.biopax.org/relea... | |
| http://www.biopax.org/relea... |
4.6.1.2,
ANP-A,
ANPR-A,
Atrial natriuretic peptide receptor type A,
GC-A,
Guanylate cyclase A,
NPR-A
|
| http://www.biopax.org/relea... |
FUNCTION: Receptor for the atrial natriuretic peptide NPPA/ANP and the brain natriuretic peptide NPPB/BNP which are potent vasoactive hormones playing a key role in cardiovascular homeostasis. Has guanylate cyclase activity upon binding of the ligand. CATALYTIC ACTIVITY: GTP = 3',5'-cyclic GMP + diphosphate. SUBUNIT: Homodimer (By similarity). SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein. PTM: Phosphorylation of the protein kinase-like domain is required for full activation by ANP (By similarity). DISRUPTION PHENOTYPE: Mice display systemic hypertension associated with cardiac hypertrophy and ventricular enlargement. SIMILARITY: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. SIMILARITY: Contains 1 guanylate cyclase domain. SIMILARITY: Contains 1 protein kinase domain. GENE SYNONYMS: Npra. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.
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