Linked Life Data

CPATH-124324

Source:http://cbio.mskcc.org/cpath#CPATH-124324

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SubjectPredicateObjectContext
cpath:CPATH-124324rdf:typehttp://www.biopax.org/relea...lld:biogrid
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cpath:CPATH-124324http://www.biopax.org/relea...cpath:CPATH-LOCAL-517034lld:biogrid
cpath:CPATH-124324http://www.biopax.org/relea...Kallikrein-1lld:biogrid
cpath:CPATH-124324http://www.biopax.org/relea...KLK1_HUMANlld:biogrid
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cpath:CPATH-124324http://www.biopax.org/relea...3.4.21.35lld:biogrid
cpath:CPATH-124324http://www.biopax.org/relea...Kidney/pancreas/salivary gland kallikreinlld:biogrid
cpath:CPATH-124324http://www.biopax.org/relea...Tissue kallikreinlld:biogrid
cpath:CPATH-124324http://www.biopax.org/relea...FUNCTION: Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin. CATALYTIC ACTIVITY: Preferential cleavage of Arg-|-Xaa bonds in small molecule substrates. Highly selective action to release kallidin (lysyl-bradykinin) from kininogen involves hydrolysis of Met-|-Xaa or Leu-|-Xaa. ALTERNATIVE PRODUCTS: Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P06870-1; Sequence=Displayed; Name=2; IsoId=P06870-2; Sequence=VSP_037483; TISSUE SPECIFICITY: Isoform 2 is expressed in pancreas, salivary glands, kidney, colon, prostate gland, testis, spleen and the colon adenocarcinoma cell line T84. PTM: The O-linked polysaccharides on Ser-93, Ser-104 and Ser-167 are probably the mucin type linked to GalNAc. In PubMed:3163150, GalNAc was detected with the corresponding peptides but not located. SIMILARITY: Belongs to the peptidase S1 family. Kallikrein subfamily. SIMILARITY: Contains 1 peptidase S1 domain. WEB RESOURCE: Name=Wikipedia; Note=Kallikrein entry; URL="http://en.wikipedia.org/wiki/Kallikrein"; WEB RESOURCE: Name=SeattleSNPs; URL="http://pga.gs.washington.edu/data/klk1/"; COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.lld:biogrid
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cpath:CPATH-124324skos:closeMatchentrez-gene:3816lld:mappings
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