| Predicate | Object |
|---|---|
| rdf:type | |
| http://www.biopax.org/relea... |
cpath:CPATH-LOCAL-513342,
cpath:CPATH-LOCAL-513343,
cpath:CPATH-LOCAL-513344,
cpath:CPATH-LOCAL-513345,
cpath:CPATH-LOCAL-513346,
cpath:CPATH-LOCAL-513347,
cpath:CPATH-LOCAL-513348,
cpath:CPATH-LOCAL-513349,
cpath:CPATH-LOCAL-513350,
cpath:CPATH-LOCAL-513351,
cpath:CPATH-LOCAL-513352,
cpath:CPATH-LOCAL-517034
|
| http://www.biopax.org/relea... |
Kallikrein-1
|
| http://www.biopax.org/relea... |
KLK1_HUMAN
|
| http://www.biopax.org/relea... | |
| http://www.biopax.org/relea... |
3.4.21.35,
Kidney/pancreas/salivary gland kallikrein,
Tissue kallikrein
|
| http://www.biopax.org/relea... |
FUNCTION: Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin. CATALYTIC ACTIVITY: Preferential cleavage of Arg-|-Xaa bonds in small molecule substrates. Highly selective action to release kallidin (lysyl-bradykinin) from kininogen involves hydrolysis of Met-|-Xaa or Leu-|-Xaa. ALTERNATIVE PRODUCTS: Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P06870-1; Sequence=Displayed; Name=2; IsoId=P06870-2; Sequence=VSP_037483; TISSUE SPECIFICITY: Isoform 2 is expressed in pancreas, salivary glands, kidney, colon, prostate gland, testis, spleen and the colon adenocarcinoma cell line T84. PTM: The O-linked polysaccharides on Ser-93, Ser-104 and Ser-167 are probably the mucin type linked to GalNAc. In PubMed:3163150, GalNAc was detected with the corresponding peptides but not located. SIMILARITY: Belongs to the peptidase S1 family. Kallikrein subfamily. SIMILARITY: Contains 1 peptidase S1 domain. WEB RESOURCE: Name=Wikipedia; Note=Kallikrein entry; URL="http://en.wikipedia.org/wiki/Kallikrein"; WEB RESOURCE: Name=SeattleSNPs; URL="http://pga.gs.washington.edu/data/klk1/"; COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.
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| skos:exactMatch | |
| skos:closeMatch |