Linked Life Data

CPATH-123288

Source:http://cbio.mskcc.org/cpath#CPATH-123288

Statements in which the resource exists.
SubjectPredicateObjectContext
cpath:CPATH-123288rdf:typehttp://www.biopax.org/relea...lld:biogrid
cpath:CPATH-123288http://www.biopax.org/relea...cpath:CPATH-LOCAL-508715lld:biogrid
cpath:CPATH-123288http://www.biopax.org/relea...cpath:CPATH-LOCAL-508716lld:biogrid
cpath:CPATH-123288http://www.biopax.org/relea...cpath:CPATH-LOCAL-508717lld:biogrid
cpath:CPATH-123288http://www.biopax.org/relea...cpath:CPATH-LOCAL-508718lld:biogrid
cpath:CPATH-123288http://www.biopax.org/relea...cpath:CPATH-LOCAL-508719lld:biogrid
cpath:CPATH-123288http://www.biopax.org/relea...cpath:CPATH-LOCAL-516517lld:biogrid
cpath:CPATH-123288http://www.biopax.org/relea...Arachidonate 5-lipoxygenaselld:biogrid
cpath:CPATH-123288http://www.biopax.org/relea...LOX5_HUMANlld:biogrid
cpath:CPATH-123288http://www.biopax.org/relea...cpath:CPATH-LOCAL-508713lld:biogrid
cpath:CPATH-123288http://www.biopax.org/relea...1.13.11.34lld:biogrid
cpath:CPATH-123288http://www.biopax.org/relea...5-LOlld:biogrid
cpath:CPATH-123288http://www.biopax.org/relea...5-lipoxygenaselld:biogrid
cpath:CPATH-123288http://www.biopax.org/relea...FUNCTION: Catalyzes the first step in leukotriene biosynthesis, and thereby plays a role in inflammatory processes. CATALYTIC ACTIVITY: Arachidonate + O(2) = leukotriene A(4) + H(2)O. COFACTOR: Binds 1 iron ion per subunit. COFACTOR: Binds 2 calcium ions per subunit (By similarity). PATHWAY: Lipid metabolism; leukotriene A4 biosynthesis. SUBUNIT: Interacts with ALOX5AP and LTC4S. SUBCELLULAR LOCATION: Cytoplasm. Nucleus matrix. Nucleus membrane; Peripheral membrane protein. Note=Shuttles between cytoplasm and nucleus. Found exclusively in the nucleus, when phosphorylated on Ser-272. Calcium binding promotes translocation from the cytosol and the nuclear matrix to the nuclear envelope and membrane association. PTM: Serine phosphorylation by MAPKAPK2 is stimulated by arachidonic acid. Phosphorylation on Ser-523 by PKA has an inhibitory effect. Phosphorylation on Ser-272 prevents export from the nucleus. SIMILARITY: Belongs to the lipoxygenase family. SIMILARITY: Contains 1 lipoxygenase domain. SIMILARITY: Contains 1 PLAT domain. WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/ALOX5ID42985ch10q11.html"; GENE SYNONYMS: LOG5. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.lld:biogrid
cpath:CPATH-123288skos:exactMatchuniprot-protein:P09917lld:mappings
cpath:CPATH-123288skos:closeMatchentrez-gene:240lld:mappings
cpath:CPATH-LOCAL-11055580http://www.biopax.org/relea...cpath:CPATH-123288lld:biogrid
cpath:CPATH-LOCAL-11112295http://www.biopax.org/relea...cpath:CPATH-123288lld:biogrid
cpath:CPATH-LOCAL-11141920http://www.biopax.org/relea...cpath:CPATH-123288lld:biogrid
cpath:CPATH-LOCAL-11323780http://www.biopax.org/relea...cpath:CPATH-123288lld:biogrid
cpath:CPATH-LOCAL-11353090http://www.biopax.org/relea...cpath:CPATH-123288lld:biogrid
cpath:CPATH-LOCAL-11725930http://www.biopax.org/relea...cpath:CPATH-123288lld:biogrid
cpath:CPATH-LOCAL-11865669http://www.biopax.org/relea...cpath:CPATH-123288lld:biogrid