| Predicate | Object |
|---|---|
| rdf:type | |
| http://www.biopax.org/relea... | |
| http://www.biopax.org/relea... |
Arachidonate 5-lipoxygenase
|
| http://www.biopax.org/relea... |
LOX5_HUMAN
|
| http://www.biopax.org/relea... | |
| http://www.biopax.org/relea... |
1.13.11.34,
5-LO,
5-lipoxygenase
|
| http://www.biopax.org/relea... |
FUNCTION: Catalyzes the first step in leukotriene biosynthesis, and thereby plays a role in inflammatory processes. CATALYTIC ACTIVITY: Arachidonate + O(2) = leukotriene A(4) + H(2)O. COFACTOR: Binds 1 iron ion per subunit. COFACTOR: Binds 2 calcium ions per subunit (By similarity). PATHWAY: Lipid metabolism; leukotriene A4 biosynthesis. SUBUNIT: Interacts with ALOX5AP and LTC4S. SUBCELLULAR LOCATION: Cytoplasm. Nucleus matrix. Nucleus membrane; Peripheral membrane protein. Note=Shuttles between cytoplasm and nucleus. Found exclusively in the nucleus, when phosphorylated on Ser-272. Calcium binding promotes translocation from the cytosol and the nuclear matrix to the nuclear envelope and membrane association. PTM: Serine phosphorylation by MAPKAPK2 is stimulated by arachidonic acid. Phosphorylation on Ser-523 by PKA has an inhibitory effect. Phosphorylation on Ser-272 prevents export from the nucleus. SIMILARITY: Belongs to the lipoxygenase family. SIMILARITY: Contains 1 lipoxygenase domain. SIMILARITY: Contains 1 PLAT domain. WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/ALOX5ID42985ch10q11.html"; GENE SYNONYMS: LOG5. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.
|
| skos:exactMatch | |
| skos:closeMatch |