Linked Life Data

CPATH-118361

Source:http://cbio.mskcc.org/cpath#CPATH-118361

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SubjectPredicateObjectContext
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cpath:CPATH-118361http://www.biopax.org/relea...cpath:CPATH-LOCAL-491650lld:biogrid
cpath:CPATH-118361http://www.biopax.org/relea...Vasopressin-neurophysin 2-copeptinlld:biogrid
cpath:CPATH-118361http://www.biopax.org/relea...NEU2_HUMANlld:biogrid
cpath:CPATH-118361http://www.biopax.org/relea...cpath:CPATH-LOCAL-487714lld:biogrid
cpath:CPATH-118361http://www.biopax.org/relea...AVP-NPIIlld:biogrid
cpath:CPATH-118361http://www.biopax.org/relea...Copeptinlld:biogrid
cpath:CPATH-118361http://www.biopax.org/relea...Neurophysin 2lld:biogrid
cpath:CPATH-118361http://www.biopax.org/relea...Arg-vasopressinlld:biogrid
cpath:CPATH-118361http://www.biopax.org/relea...Neurophysin-IIlld:biogrid
cpath:CPATH-118361http://www.biopax.org/relea...FUNCTION: Neurophysin 2 specifically binds vasopressin. FUNCTION: Vasopressin has a direct antidiuretic action on the kidney, it also causes vasoconstriction of the peripheral vessels. SUBCELLULAR LOCATION: Secreted. DISEASE: Defects in AVP are the cause of autosomal dominant neurohypophyseal diabetes insipidus (ADNDI) [MIM:125700]. ADNDI is characterized by persistent thirst, polydipsia and polyuria. The disease is transmitted in an autosomal dominant mode and appears to be largely if not completely penetrant. DISEASE: Defects in AVP are the cause of autosomal recessive neurohypophyseal diabetes insipidus (ARNDI) [MIM:125700]. ARNDI is characterized by persistent thirst, polydipsia and polyuria. Most mutations are hypothesized to trigger neurodegeneration via disruption of preproAVP-NPII processing. SIMILARITY: Belongs to the vasopressin/oxytocin family. WEB RESOURCE: Name=GeneReviews; URL="http://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/AVP"; WEB RESOURCE: Name=Wikipedia; Note=Vasopressin entry; URL="http://en.wikipedia.org/wiki/Vasopressin"; GENE SYNONYMS: ARVP VP. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.lld:biogrid
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