| Predicate | Object |
|---|---|
| rdf:type | |
| http://www.biopax.org/relea... | |
| http://www.biopax.org/relea... |
Vasopressin-neurophysin 2-copeptin
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| http://www.biopax.org/relea... |
NEU2_HUMAN
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| http://www.biopax.org/relea... | |
| http://www.biopax.org/relea... |
AVP-NPII,
Arg-vasopressin,
Copeptin,
Neurophysin 2,
Neurophysin-II
|
| http://www.biopax.org/relea... |
FUNCTION: Neurophysin 2 specifically binds vasopressin. FUNCTION: Vasopressin has a direct antidiuretic action on the kidney, it also causes vasoconstriction of the peripheral vessels. SUBCELLULAR LOCATION: Secreted. DISEASE: Defects in AVP are the cause of autosomal dominant neurohypophyseal diabetes insipidus (ADNDI) [MIM:125700]. ADNDI is characterized by persistent thirst, polydipsia and polyuria. The disease is transmitted in an autosomal dominant mode and appears to be largely if not completely penetrant. DISEASE: Defects in AVP are the cause of autosomal recessive neurohypophyseal diabetes insipidus (ARNDI) [MIM:125700]. ARNDI is characterized by persistent thirst, polydipsia and polyuria. Most mutations are hypothesized to trigger neurodegeneration via disruption of preproAVP-NPII processing. SIMILARITY: Belongs to the vasopressin/oxytocin family. WEB RESOURCE: Name=GeneReviews; URL="http://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/AVP"; WEB RESOURCE: Name=Wikipedia; Note=Vasopressin entry; URL="http://en.wikipedia.org/wiki/Vasopressin"; GENE SYNONYMS: ARVP VP. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.
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