Linked Life Data

CPATH-104558

Source:http://cbio.mskcc.org/cpath#CPATH-104558

Statements in which the resource exists.
SubjectPredicateObjectContext
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cpath:CPATH-104558http://www.biopax.org/relea...FUNCTION: Receptor with high affinity for TNFSF2/TNF-alpha and approximately 5-fold lower affinity for homotrimeric TNFSF1/lymphotoxin-alpha. The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2. This receptor mediates most of the metabolic effects of TNF-alpha. Isoform 2 blocks TNF-alpha-induced apoptosis, which suggests that it regulates TNF-alpha function by antagonizing its biological activity. SUBUNIT: Binds to TRAF2. SUBCELLULAR LOCATION: Isoform 1: Cell membrane; Single-pass type I membrane protein. SUBCELLULAR LOCATION: Isoform 2: Secreted. SUBCELLULAR LOCATION: Tumor necrosis factor-binding protein 2: Secreted. ALTERNATIVE PRODUCTS: Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P20333-1; Sequence=Displayed; Name=2; Synonyms=DS-TNFR2(Delta7,8), sTNFR2; IsoId=P20333-2; Sequence=VSP_011826, VSP_011827; PTM: Phosphorylated; mainly on serine residues and with a very low level on threonine residues. PTM: A soluble form (tumor necrosis factor binding protein 2) is produced from the membrane form by proteolytic processing. PHARMACEUTICAL: Available under the name Enbrel (Immunex and Wyeth-Ayerst). Used to treat moderate to severe rheumatoid arthritis (RA). Enbrel consist of the extracellular ligand-binding portion of TNFRSF1B linked to an immunoglobulin Fc chain. It binds to TNF-alpha and blocks its interactions with receptors. SIMILARITY: Contains 4 TNFR-Cys repeats. WEB RESOURCE: Name=SeattleSNPs; URL="http://pga.gs.washington.edu/data/tnfrsf1b/"; WEB RESOURCE: Name=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/tnfrsf1b/"; WEB RESOURCE: Name=Enbrel; Note=Clinical information on Enbrel; URL="http://www.enbrel.com/index.jspx"; GENE SYNONYMS: TNFBR TNFR2. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.lld:biogrid
cpath:CPATH-104558http://www.biopax.org/relea...FUNCTION: Receptor with high affinity for TNFSF2/TNF-alpha and approximately 5-fold lower affinity for homotrimeric TNFSF1/lymphotoxin-alpha. The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2. This receptor mediates most of the metabolic effects of TNF-alpha. Isoform 2 blocks TNF-alpha-induced apoptosis, which suggests that it regulates TNF-alpha function by antagonizing its biological activity. SUBUNIT: Binds to TRAF2. SUBCELLULAR LOCATION: Isoform 1: Cell membrane; Single-pass type I membrane protein. SUBCELLULAR LOCATION: Isoform 2: Secreted. SUBCELLULAR LOCATION: Tumor necrosis factor-binding protein 2: Secreted. ALTERNATIVE PRODUCTS: Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P20333-1; Sequence=Displayed; Name=2; Synonyms=DS-TNFR2(Delta7,8), sTNFR2; IsoId=P20333-2; Sequence=VSP_011826, VSP_011827; PTM: Phosphorylated; mainly on serine residues and with a very low level on threonine residues. PTM: A soluble form (tumor necrosis factor binding protein 2) is produced from the membrane form by proteolytic processing. PHARMACEUTICAL: Available under the name Enbrel (Immunex and Wyeth-Ayerst). Used to treat moderate to severe rheumatoid arthritis (RA). Enbrel consist of the extracellular ligand-binding portion of TNFRSF1B linked to an immunoglobulin Fc chain. It binds to TNF-alpha and blocks its interactions with receptors. SIMILARITY: Contains 4 TNFR-Cys repeats. WEB RESOURCE: Name=SeattleSNPs; URL="http://pga.gs.washington.edu/data/tnfrsf1b/"; WEB RESOURCE: Name=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/tnfrsf1b/"; WEB RESOURCE: Name=Enbrel; Note=Clinical information on Enbrel; URL="http://www.enbrel.com/index.jspx"; GENE SYNONYMS: TNFBR TNFR2. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.lld:cellmap
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