| Predicate | Object |
|---|---|
| rdf:type | |
| http://www.biopax.org/relea... |
cpath:CPATH-LOCAL-433969,
cpath:CPATH-LOCAL-433969,
cpath:CPATH-LOCAL-433970,
cpath:CPATH-LOCAL-433970,
cpath:CPATH-LOCAL-433971,
cpath:CPATH-LOCAL-433971,
cpath:CPATH-LOCAL-433972,
cpath:CPATH-LOCAL-433972,
cpath:CPATH-LOCAL-433973,
cpath:CPATH-LOCAL-433973,
cpath:CPATH-LOCAL-433974,
cpath:CPATH-LOCAL-433974,
cpath:CPATH-LOCAL-433975,
cpath:CPATH-LOCAL-433975,
cpath:CPATH-LOCAL-433976,
cpath:CPATH-LOCAL-433976,
cpath:CPATH-LOCAL-437616,
cpath:CPATH-LOCAL-437616
|
| http://www.biopax.org/relea... |
Tumor necrosis factor receptor superfamily member 1B,
Tumor necrosis factor receptor superfamily member 1B
|
| http://www.biopax.org/relea... |
TNR1B_HUMAN,
TNR1B_HUMAN
|
| http://www.biopax.org/relea... | |
| http://www.biopax.org/relea... |
CD120b,
CD120b,
Etanercept,
Etanercept,
TBP-2,
TBP-2,
TBPII,
TBPII,
TNF-R2,
TNF-R2,
TNF-RII,
TNF-RII,
TNFR-II,
TNFR-II,
Tumor necrosis factor receptor 2,
Tumor necrosis factor receptor 2,
Tumor necrosis factor receptor superfamily member 1b, membrane form,
Tumor necrosis factor receptor superfamily member 1b, membrane form,
Tumor necrosis factor receptor type II,
Tumor necrosis factor receptor type II,
Tumor necrosis factor-binding protein 2,
Tumor necrosis factor-binding protein 2,
p75,
p75,
p80 TNF-alpha receptor,
p80 TNF-alpha receptor
|
| http://www.biopax.org/relea... |
FUNCTION: Receptor with high affinity for TNFSF2/TNF-alpha and approximately 5-fold lower affinity for homotrimeric TNFSF1/lymphotoxin-alpha. The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2. This receptor mediates most of the metabolic effects of TNF-alpha. Isoform 2 blocks TNF-alpha-induced apoptosis, which suggests that it regulates TNF-alpha function by antagonizing its biological activity. SUBUNIT: Binds to TRAF2. SUBCELLULAR LOCATION: Isoform 1: Cell membrane; Single-pass type I membrane protein. SUBCELLULAR LOCATION: Isoform 2: Secreted. SUBCELLULAR LOCATION: Tumor necrosis factor-binding protein 2: Secreted. ALTERNATIVE PRODUCTS: Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P20333-1; Sequence=Displayed; Name=2; Synonyms=DS-TNFR2(Delta7,8), sTNFR2; IsoId=P20333-2; Sequence=VSP_011826, VSP_011827; PTM: Phosphorylated; mainly on serine residues and with a very low level on threonine residues. PTM: A soluble form (tumor necrosis factor binding protein 2) is produced from the membrane form by proteolytic processing. PHARMACEUTICAL: Available under the name Enbrel (Immunex and Wyeth-Ayerst). Used to treat moderate to severe rheumatoid arthritis (RA). Enbrel consist of the extracellular ligand-binding portion of TNFRSF1B linked to an immunoglobulin Fc chain. It binds to TNF-alpha and blocks its interactions with receptors. SIMILARITY: Contains 4 TNFR-Cys repeats. WEB RESOURCE: Name=SeattleSNPs; URL="http://pga.gs.washington.edu/data/tnfrsf1b/"; WEB RESOURCE: Name=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/tnfrsf1b/"; WEB RESOURCE: Name=Enbrel; Note=Clinical information on Enbrel; URL="http://www.enbrel.com/index.jspx"; GENE SYNONYMS: TNFBR TNFR2. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.,
FUNCTION: Receptor with high affinity for TNFSF2/TNF-alpha and approximately 5-fold lower affinity for homotrimeric TNFSF1/lymphotoxin-alpha. The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2. This receptor mediates most of the metabolic effects of TNF-alpha. Isoform 2 blocks TNF-alpha-induced apoptosis, which suggests that it regulates TNF-alpha function by antagonizing its biological activity. SUBUNIT: Binds to TRAF2. SUBCELLULAR LOCATION: Isoform 1: Cell membrane; Single-pass type I membrane protein. SUBCELLULAR LOCATION: Isoform 2: Secreted. SUBCELLULAR LOCATION: Tumor necrosis factor-binding protein 2: Secreted. ALTERNATIVE PRODUCTS: Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P20333-1; Sequence=Displayed; Name=2; Synonyms=DS-TNFR2(Delta7,8), sTNFR2; IsoId=P20333-2; Sequence=VSP_011826, VSP_011827; PTM: Phosphorylated; mainly on serine residues and with a very low level on threonine residues. PTM: A soluble form (tumor necrosis factor binding protein 2) is produced from the membrane form by proteolytic processing. PHARMACEUTICAL: Available under the name Enbrel (Immunex and Wyeth-Ayerst). Used to treat moderate to severe rheumatoid arthritis (RA). Enbrel consist of the extracellular ligand-binding portion of TNFRSF1B linked to an immunoglobulin Fc chain. It binds to TNF-alpha and blocks its interactions with receptors. SIMILARITY: Contains 4 TNFR-Cys repeats. WEB RESOURCE: Name=SeattleSNPs; URL="http://pga.gs.washington.edu/data/tnfrsf1b/"; WEB RESOURCE: Name=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/tnfrsf1b/"; WEB RESOURCE: Name=Enbrel; Note=Clinical information on Enbrel; URL="http://www.enbrel.com/index.jspx"; GENE SYNONYMS: TNFBR TNFR2. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.
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| skos:exactMatch | |
| skos:closeMatch |