Linked Life Data

CPATH-1033

Source:http://cbio.mskcc.org/cpath#CPATH-1033

Statements in which the resource exists.
SubjectPredicateObjectContext
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cpath:CPATH-1033http://www.biopax.org/relea...FUNCTION: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. PATHWAY: Protein modification; protein ubiquitination. SUBUNIT: The APC/C is composed of at least 12 subunits. Interacts with RB. SUBCELLULAR LOCATION: Nucleus. PTM: Phosphorylated. Phosphorylation on Ser-426 and Thr-446 occurs specifically during mitosis. SIMILARITY: Belongs to the APC3/CDC27 family. SIMILARITY: Contains 9 TPR repeats. WEB RESOURCE: Name=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/cdc27/"; GENE SYNONYMS: ANAPC3 D0S1430E D17S978E. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.lld:biogrid
cpath:CPATH-1033http://www.biopax.org/relea...FUNCTION: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. PATHWAY: Protein modification; protein ubiquitination. SUBUNIT: The APC/C is composed of at least 12 subunits. Interacts with RB. SUBCELLULAR LOCATION: Nucleus. PTM: Phosphorylated. Phosphorylation on Ser-426 and Thr-446 occurs specifically during mitosis. SIMILARITY: Belongs to the APC3/CDC27 family. SIMILARITY: Contains 9 TPR repeats. WEB RESOURCE: Name=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/cdc27/"; GENE SYNONYMS: ANAPC3 D0S1430E D17S978E. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.lld:cellmap
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