Source:http://linkedlifedata.com/resource/chebi/id/CHEBI:66919
| Predicate | Object |
|---|---|
| rdf:type | |
| skos:definition |
"A pyrazole substituted at position 1 by a 2-cyano-1-cyclopentylethyl group and at position 3 by a pyrrolo[2,3-d]pyrimidin-4-yl group. Used as the phosphate salt for the treatment of patients with intermediate or high-risk myelofibrosis, including primary myelofibrosis, post-polycythemia vera myelofibrosis and post-essential thrombocythemia myelofibrosis." []
|
| skos:inScheme | |
| skos:prefLabel |
ruxolitinib
|
| skos:altLabel |
(3R)-3-cyclopentyl-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]propanenitrile
|
| skos:notation |
ChemIDplus:941678-49-5 "CAS Registry Number",
CiteXplore:21602517 "PubMed citation",
CiteXplore:21919691 "PubMed citation",
CiteXplore:21926964 "PubMed citation",
CiteXplore:22034658 "PubMed citation",
CiteXplore:22227528 "PubMed citation",
CiteXplore:22279053 "PubMed citation",
CiteXplore:22281165 "PubMed citation",
CiteXplore:22375970 "PubMed citation",
CiteXplore:22375971 "PubMed citation",
CiteXplore:22399854 "PubMed citation",
CiteXplore:22422826 "PubMed citation",
CiteXplore:22474318 "PubMed citation",
CiteXplore:22544377 "PubMed citation",
CiteXplore:22718840 "PubMed citation",
CiteXplore:22830345 "PubMed citation",
KEGG DRUG:941678-49-5 "CAS Registry Number",
KEGG DRUG:D09959 "KEGG DRUG",
Patent:US2008312258 "Patent",
Patent:US2010190981 "Patent",
Reaxys:18703668 "Reaxys Registry Number",
Wikipedia:Ruxolitinib "Wikipedia"
|
| skos:broader | |
| skos:relatedSynonym |
ruxolitinib,
INCB018424,
C17H18N6,
N#CC[C@H](C1CCCC1)n1cc(cn1)-c1ncnc2[nH]ccc12,
InChI=1S/C17H18N6/c18-7-5-15(12-3-1-2-4-12)23-10-13(9-22-23)16-14-6-8-19-17(14)21-11-20-16/h6,8-12,15H,1-5H2,(H,19,20,21)/t15-/m1/s1,
InChIKey=HFNKQEVNSGCOJV-OAHLLOKOSA-N
|