Source:http://www.reactome.org/biopax/48892TemplateReaction9
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Authored: Ferrer, J, Tello-Ruiz, MK, 2008--0-5-,
Edited: Tello-Ruiz, MK, 2006-12-19 19:02:30,
Reviewed: Jensen, J, 2008-05-12 21:46:53,
The Ngn3 gene is transcribed, its mRNA is translated, and the protein product is transported to the nucleus during morphogenesis of the pancreas. Ngn3 transcription requires the activity of the Hnf6 transcription factor - in vivo, expression of Ngn3 was almost abolished in murine Hnf6 -/- embryos (Jacquemin et al. 2000). Hes1 represses Ngn3 transcription. Hes1 is an effector of the Notch pathway, which in turn negatively regulates pancreatic development. Lack of Delta-like gene 1 (Notch receptor) or RBP-Jkappa (Notch signaling intracellular mediator) leads to precocious pancreatic endocrine differentiation. Inactivation of Notch/Hes1 is critical for endocrine (and progenitor/exocrine) pancreatic differentiation (Apelqvist et al. 1999; Jensen et al. 2000). In vivo, the interplay between Hnf6 and Hes1 deteremines the timing and level of Ngn3 expression, which is critical for normal development of the pancreas.
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Hnf6-dependent synthesis of Ngn3 protein during morphogenesis
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