Source:http://www.reactome.org/biopax/48892TemplateReaction11
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Authored: Ferrer, J, Tello-Ruiz, MK, 2008--0-5-,
Edited: Tello-Ruiz, MK, 2006-12-19 19:02:30,
Reviewed: Jensen, J, 2008-05-12 21:46:53,
Studies in Hnf6/Onecut1 knock-out embryos showed that HNF6 is required for expression of the Onecut3 gene in the mouse endoderm, and that both protein products, HNF6/ONECUT1 and ONECUT3 co-localize in the endoderm and in embryonic pancreas (Pierreux et al. 2004). The same authors demonstrated through transfection, chromatin immunoprecipitation, and whole embryo electroporation experiments, that HNF6/ONECUT1 binds to and stimulates the expression of Onecut3.
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HNF6 transactivates Onecut3 during morphogenesis
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