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biopax3:comment |
The HJURP complex binds free, newly synthesized CENPA-H4 tetramers. A direct interaction occurs between HJURP and CENPA. The CATD domain of CENPA is sufficient for the interaction. The complex then localizes to the centromere in early G1 phase. HJURP is required for deposition of new CENPA-containing nucleosomes.
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biopax3:evidenceCode |