| Predicate | Object |
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| biopax3:comment |
DCC interacts with the SH3/SH2 adaptor NCK1 in commissural neurons. This interaction is direct and requires the SH3 but not SH2 domains of NCK1. NCK1 can recruit Rac, Cdc42 and their effectors Pak and N-WASP to the activated receptor, thereby providing a direct link between DCC, Rho GTPases and numerous downstream signaling components that regulate the actin cytoskeleton.
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| biopax3:xref | |
| biopax3:evidenceCode |