| Predicate | Object |
|---|---|
| rdf:type | |
| biopax3:comment |
The CCR4-NOT complex hydrolyzes adenosine residues at the 3' end of polyadenylated mRNA, shortening the number of adenosine residues to about 10-15 residues and yielding adenosine 5'-monophosphate. CNOT6 and CNOT6L are the exoribonucleases responsible for hydrolysis. Activity of the CCR4-NOT complex is inhibited by PABP bound to the poly(A) tail of the mRNA. The trigger for activation of deadenylation by the CCR4-NOT complex is unknown. Complexes containing CNOT7 rather than CNOT8 appear to be responsible for cytoplasmic mRNA decay.
|
| biopax3:xref |
http://identifiers.org/pubmed/10637334,
http://identifiers.org/pubmed/11283721,
http://identifiers.org/pubmed/11889047,
http://identifiers.org/pubmed/14749774,
http://identifiers.org/pubmed/15475613,
http://identifiers.org/pubmed/16141059,
http://identifiers.org/pubmed/16284618,
http://identifiers.org/pubmed/17245413,
http://identifiers.org/pubmed/18625844,
http://identifiers.org/pubmed/19239894,
http://identifiers.org/pubmed/19558367
|
| biopax3:evidenceCode |