| Predicate | Object |
|---|---|
| rdf:type | |
| biopax3:comment |
The PARN exoribonuclease hydrolyzes adenosine residues at the 3' ends of polyadenylated mRNA, shortening the poly(A) tail from about 80 adenosine residues to about 10-15 residues and yielding adenosine 5'-monophosphate. PARN interacts simultaneously with the poly(A) tail and with the 7-methylguanosine cap of the mRNA, therefore it is believed that PARN displaces the eIF4F cap-binding complex. The trigger for deadenylation by PARN is unknown. PARN is also part of a complex that regulates poly(A) tail length and hence translation in developing oocytes.
|
| biopax3:xref |
http://identifiers.org/pubmed/10882133,
http://identifiers.org/pubmed/11283721,
http://identifiers.org/pubmed/1355481,
http://identifiers.org/pubmed/14749774,
http://identifiers.org/pubmed/15475613,
http://identifiers.org/pubmed/16141059,
http://identifiers.org/pubmed/17052452,
http://identifiers.org/pubmed/17245413,
http://identifiers.org/pubmed/19239894,
http://identifiers.org/pubmed/9099687
|
| biopax3:evidenceCode |