| Predicate | Object |
|---|---|
| rdf:type | |
| biopax3:comment |
Raf is a downstream effector of ras. Raf is activated upon phosphorylation at S338, oligomerization and membrane localization. Membrane localization is facilitated by ras. Interaction of ras with raf is a necessary step but not sufficient for raf activation. Other unknown protein partner interactions are required for raf activation. Raf further activates MAP kinase.
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| biopax3:xref | |
| biopax3:evidenceCode |