| Predicate | Object |
|---|---|
| rdf:type | |
| biopax3:comment |
20alpha,22beta-hydroxycholesterol, NADPH + H+, and O2 react to form pregnenolone, isocaproaldehyde, NADP+ and H2O. This cleavage reaction is catalyzed by CYP11A (P450scc) associated with the inner mitochondrial membrane. Pregnenolone is substantially more hydrophilic than cholesterol and hydroxycholesterol and is released into the mitochondrial matrix.
|
| biopax3:xref | |
| biopax3:evidenceCode |