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Intracellular pools of calcium serve as the source for inositol 1,4,5-trisphosphate (IP3) -induced alterations in cytoplasmic free calcium. In most human cells calcium is stored in the lumen of the sarco/endoplastic reticulum by ATPases known as SERCAs. In platelets, SERCAs transport calcium into the platelet dense tubular network. SERCAs are P-type ATPases, similar to the plasma membrane Na and Ca-ATPases. Humans have three genes for SERCA pumps; SERCA1, SERCA2 and SERCA3. Studies on SERCA1 suggest that it binds two Ca ions from the cytoplasm and is subsequently phosphorylated at Asp351 before translocating the Ca into the SR lumen. There is a counter transport of two or possibly three protons ensuring partial charge balancing.
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