| Predicate | Object |
|---|---|
| rdf:type | |
| biopax3:comment |
Acyl ghrelin and C-ghrelin are secreted from secretory granules into the bloodstream. Five forms of acyl ghrelin have been detected: octanoyl ghrelin-28, decanoyl ghrelin-28, octanoyl ghrelin-27, decanoyl ghrelin-27, and decenoyl ghrelin-28. Unacylated ghrelin (des-acyl ghrelin) occurs at higher levels than acyl ghrelin however its function and mechanism of generation are controversial. The function, if any, of C-ghrelin is also unknown.<br>Secretion of ghrelin is stimulated by insulin-like growth factor-1 and muscarinic agonists; Secretion is inhibited by insulin, somatotropin, leptin, glucose, glucagon, and fatty acids. Carbohydrates have more inhibitory effect than fat does. The mechanisms by which the regulation is effected are unknown.
|
| biopax3:xref |
http://identifiers.org/pubmed/11089560,
http://identifiers.org/pubmed/11600536,
http://identifiers.org/pubmed/11756331,
http://identifiers.org/pubmed/12354137,
http://identifiers.org/pubmed/12553549,
http://identifiers.org/pubmed/14599721,
http://identifiers.org/pubmed/15126574,
http://identifiers.org/pubmed/17595255,
http://identifiers.org/pubmed/18396350,
http://identifiers.org/pubmed/19280057
|
| biopax3:evidenceCode |