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biopax3:comment |
IGFBP 3 binds IGF I or IGF II via the conserved N terminus and C terminus of IGFBP 3. IGFBP 3 also binds ALS via the C terminal portion of IGFBP 3. The interaction is dependent on the glycosylation of ALS.<br>IGFBP 3, which binds most IGF in the body, is enriched in follicular fluid and found in many other tissues. IGFBP 3 may be cleaved by plasmin, thrombin, Prostate specific Antigen (PSA), Matrix Metalloprotease 1, and Matrix Metalloprotease 2. IGFBP 3 also binds extracellular matrix and binding lowers its affinity for IGFs. IGFBP 3 stimulates the effects of IGFs.<br>
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