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Neurokinin B peptide (NKB) (Torricelli M et al, 2007) is a tachykinin-related neuropeptide that is highly expressed in the placenta.It can bind to its receptor, NK3 (Huang RR et al, 1992), which is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. Elevated levels of NKB in early pregnancy may be an indicator of hypertension and pre-eclampsia (Page NM et al, 2000), and treatment with certain neurokinin receptor antagonists may be useful in alleviating the symptoms.
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