48892Evidence2302

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Predicate	Object
rdf:type	biopax3:Evidence
biopax3:comment	The activated TGF-beta receptor complex is internalized by clathrin-mediated endocytosis into early endosomes. SARA resides in the membrane of early endosomes. Crystallographic studies suggest that dimeric SARA in the early endosome coordinates two R-SMAD molecules (SMAD2 and/or SMAD3) per one receptor complex.
biopax3:xref	http://identifiers.org/pubmed/9865696
biopax3:evidenceCode	http://www.reactome.org/biopax/48892EvidenceCodeVocabulary1