| Predicate | Object |
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| rdf:type | |
| biopax3:comment |
Upon phosphorylation of the R-SMAD (SMAD2/3), the conformation of the C-terminal (MH2) domain of the R-SMAD changes, lowering its affinity for the type I receptor and SARA. As a result, the phosphorylated R-SMAD dissociates from the activated receptor complex (TGFBR).
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| biopax3:xref | |
| biopax3:evidenceCode |