| Predicate | Object |
|---|---|
| rdf:type | |
| biopax3:comment |
Smad6 and Smad7, the two I-Smads, bind directly to the BMP type I receptors and recruit the ubiquitin ligase Smurf1. This reaction leads to competitive inhibition of R-Smad binding to the type I receptor and activating phosphorylation by the receptor, and also leads to BMP receptor ubiquitination and degradation.
|
| biopax3:xref | |
| biopax3:evidenceCode |