| Predicate | Object |
|---|---|
| rdf:type | |
| biopax3:comment |
E3 ubiquitin ligase CHIP (STUB1) mediates ERBB2 ubiquitination by associating with the ERBB2 indirectly, through the chaperone protein HSP90. CHIP (STUB1) ubiquitinates both ERBB2 and HSP90, leading to their proteasome-dependent degradation. Ubiquitination of ERBB2 by CHIP (STUB1) is independent of ERBB2 activation.
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| biopax3:xref | |
| biopax3:evidenceCode |