| Predicate | Object |
|---|---|
| rdf:type | |
| biopax3:comment |
The NEYTEG motif is very similar to the CBL binding motif around Tyr-1045 in EGFR. Tyrosine-phosphorylated Sprouty (hSpry) binds to CBL, which then cannot ubiquitinate EGFR. Sprouty acts as a decoy to lure CBL away from EGFR and targets it for degradation.
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| biopax3:xref | |
| biopax3:evidenceCode |