48892Evidence1575

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Predicate	Object
rdf:type	biopax3:Evidence
biopax3:comment	Protein phosphatase 1 beta (PPM1B/PP2CB) is a target for ISG15. PP2CB dephosphorylates TAK1 and suppresses TAK1/TAB1-mediated IkB alpha degradation and thereby controls the NF-kB signaling pathway, which plays a critical role in innate and adaptive immunity and cancer. ISGylation of PP2CB may block the suppressive function of the phosphatase against TAK1/TAB1 mediated NF-kB activation.
biopax3:xref	http://identifiers.org/pubmed/16872604, http://identifiers.org/pubmed/20153823, http://identifiers.org/pubmed/20946978, http://www.reactome.org/biopax/48892PublicationXref2869
biopax3:evidenceCode	http://www.reactome.org/biopax/48892EvidenceCodeVocabulary1