Source:http://www.reactome.org/biopax/48892BiochemicalReaction4359
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Authored: Garapati, P V, 2009-03-23 09:59:28,
Edited: Garapati, P V, 2009-03-23 10:00:07,
Reviewed: Kumanogoh, A, Kikutani, H, 2009-09-01,
Sema3A-mediated dissociation of FARP2 from Plexin-A is followed by activation of Rac1 by the GEF activity of released FARP2.<br>FARP2 is critical for Sema3A-mediated axonal repulsion through two independent downstream signaling pathways. Sema3A mediated disassociation of FARP2 from Plexin-A is followed by activation of Rac by GEF activity of released FARP2, binding of Rnd1 to plexin-A and down regulation of R-Ras by GAP activity of plexin-A.
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Activation of Rac1 by FARP2
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