Source:http://www.reactome.org/biopax/48892BiochemicalReaction3814
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Authored: Jassal, B, 2011-08-17,
Edited: Jassal, B, 2011-08-17,
In the second salvage step, dihydrofolate reductase (DHFR) can regenerate BH4 from BH2, a process which increases the BH4:BH2 ratio providing BH4 for coupled eNOS production of NO. In mice cell lines, DHFR inhibition or knockdown diminishes the BH4:BH2 ratio and exacerbates eNOS uncoupling (Crabtree et al. 2009).,
Reviewed: D'Eustachio, P, 2011-08-23
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Salvage - BH2 is reduced to BH4 by Dhfr
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1.5.1.3
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