Source:http://www.reactome.org/biopax/48892BiochemicalReaction1192
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Authored: Shamovsky, V, 2011-09-21,
Edited: Shamovsky, V, 2012-02-23,
In murine L929 cells Dai dimer formation enables recruitment of Tbk1 and Irf3 to the C-terminal region of Dai in response to cytosolic DNA. This interaction is DNA-dependent as Dai mutants that lack DNA binding domains neither recruited Tbk1 nor activated Irf3 (Takaoka A et al 2007).,
Reviewed: D'Eustachio, P, 2011-12-07,
Reviewed: Upton, JW, Mocarski, ES, 2012--0-2-
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Recruitment of Irf3 to activated Dai:Tbk1
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